Mineralized mice
نویسندگان
چکیده
منابع مشابه
Mineralized mice
In This Issue In This Issue Pulling on a cytokine he extracellular matrix (ECM) acts as a storage facility for tons of factors waiting to do business in the cell. Annes et al. (page 723) show that the ECM anchoring of one factor, the cytokine TGF- , is essential for its activation. The anchoring may give cells something to pull against, with the pulling mediating the activation. Most TGF- is ...
متن کاملGeneration of Evc2/Limbin global and conditional KO mice and its roles during mineralized tissue formation.
Ellis-van Creveld (EvC) syndrome (OMIM 225500) is an autosomal recessive disease characterized with chondrodysplastic dwarfism in association with abnormalities in oral cavity. Ciliary proteins EVC and EVC2 have been identified as causative genes and they play an important role on Hedgehog signal transduction. We have also identified a causative gene LIMBIN for bovine chondrodysplastic dwarfism...
متن کاملTetracyclines and mineralized tissues: review and perspectives.
INTRODUCTION The tetracyclines have proved to be an extremely important group of drugs because of their wide range of antibiotic activity (1-3). (For general background, antibiotic activity, and pharmacology of the tetracyclines, we refer the reader to recent review articles by Weinstein (1), Kucers (3), Weisblum and Davies (4), and Garrod et al. (5).) In addition, they have the unique attribut...
متن کاملHistone deacetylases and their roles in mineralized tissue regeneration
Histone acetylation is an important epigenetic mechanism that controls expression of certain genes. It includes non-sequence-based changes of chromosomal regional structure that can alter the expression of genes. Acetylation of histones is controlled by the activity of two groups of enzymes: the histone acetyltransferases (HATs) and histone deacetylases (HDACs). HDACs remove acetyl groups from ...
متن کاملMechanical properties of nacre and highly mineralized bone.
We compared the mechanical properties of 'ordinary' bovine bone, the highly mineralized bone of the rostrum of the whale Mesoplodon densirostris, and mother of pearl (nacre) of the pearl oyster Pinctada margaritifera. The rostrum and the nacre are similar in having very little organic material. However, the rostral bone is much weaker and more brittle than nacre, which in these properties is cl...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2004
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1655iti2